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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: This double-layer structure allows DPH to encapsulate and deliver probiotics in a targeted manner withinThus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailabilityalmost unchanged bioactivity in the gastrointestinal tract before release, as well as improved oral delivery

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug deliveryThis review highlights recent progresses in platelet membrane-based drug delivery and unique strategies

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 529-536 doi: 10.1007/s11705-017-1645-z

Abstract: An anticancer drug delivery system consisting of DNA nanoparticles synthesized by rolling circle amplification(RCA) was developed for prostate cancer membrane antigen (PSMA) targeted cancer therapy.The template of RCA was a DNA oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domainThe prepared DNA nanoparticles showed the potential as drug delivery system for PSMA targeting prostate

Keywords： aptamer     DNA nanoparticles     rolling circle amplification     doxorubicin     drug delivery     pH sensitive    

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: In this study, a novel Salmonella-mediated targeted expression system of tumstatin (VNP-Tum5)This study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatment

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

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Studies on preparation of folate-targeted boron liposomes as potential delivery agents for neutron capture

Wang Zhihui,Qin Linxue,Liu Dong

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 78-81

Abstract:

To prepare folate-targeted liposomes with high encapsulation efficiencyis an effective targeted drug delivery agent for boron neutron capture therapy (BNCT).efficiency for BBA liposomes in the optimal groups reached 94.8 %.The technique of preparing folate-targeted

Keywords： boron neutron capture therapy     liposomes     folate-targeted     encapsulation efficiency    

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Ca-Alginate-Based Janus Capsules with a Pumping Effect for Intestinal-Targeted Controlled Release Article

Shuang Wen, XiaoJie Ju, Wenying Liu, Yuqiong Liu, Xingqun Pu, Zhuang Liu, Wei Wang, Rui Xie, Yousef Faraj, Liangyin Chu

Engineering 2023, Volume 24, Issue 5,   Pages 114-125 doi: 10.1016/j.eng.2022.05.021

Abstract:

A novel intestinal-targeted θ-shaped capsule with a pumping effect for the controlled releaseoffers improved protection for the encapsulated drug in the stomach environment and excellent intestinal-targetedpotential and novel model for developing responsive pumping controlled-release systems and intestinal-targeteddrug delivery systems.

Keywords： Capsules     Ca-alginate     Intestinal-targeted delivery     Pumping effects     Controlled release    

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Toward Privacy-Preserving Personalized Recommendation Services Review

Cong Wang, Yifeng Zheng, Jinghua Jiang, Kui Ren

Engineering 2018, Volume 4, Issue 1,   Pages 21-28 doi: 10.1016/j.eng.2018.02.005

Abstract:

Recommendation systems are crucially important for the delivery of personalized services to users.With personalized recommendation services, users can enjoy a variety of targeted recommendations such

Keywords： Privacy protection     Personalized recommendation services     Targeted delivery     Collaborative filtering     Machine    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy- -PMA). Various grades of Psy- -PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

Keywords： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

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Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 245-255 doi: 10.1007/s11684-009-0044-3

Abstract: Therefore, this information may be applied for early cancer detection, classification, novel targetedRecent clinical data have revealed that targeted therapy might be the second-line therapy as an alternativeCurrently, the targeted therapies are mainly focused on two lung cancer pathways, the EGFR and the vascularTherefore, it is very important to select NSCLC patients with biomarkers to match targeted agents sothat we can further identify effectiveness of targeted therapy in the future.

Keywords： lung cancer     carcinoma     non-small cell lung cancer     molecular markers     targeted therapy    

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 521-528 doi: 10.1007/s11705-017-1612-8

Abstract: The application of gene delivery materials has been mainly focused on mammalian cells while rarely extendedThis study therefore widens the utilities of helical polypeptide as a unique category of gene deliverymaterials, and may find their promising applications toward plant gene delivery.

Keywords： α-helical polypeptide     plant gene delivery     protoplast     intact leaves     transfection    

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:
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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 276-279 doi: 10.1007/s11705-014-1426-x

Abstract: The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze ourabilities, and design the future technologies that will propel us to achieve the next level of drug deliveryEffective drug delivery systems can be developed by overcoming formulation barriers and/or biologicalso that they can be overcome by engineering manipulation of the drug delivery systems.The new generation of drug delivery scientists needs to be aware of the successes and limitations of

Keywords： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted

Keywords： bioorthogonal reaction     cancer therapy     metabolic glycoengineering     bioorthogonal catalytic patch    

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Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 473-480 doi: 10.1007/s11684-016-0479-

Abstract: We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital locatedmodels to compare the mean medical expenditures between insured and uninsured women undergoing caesarean deliveryThese findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures

Keywords： maternity insurance scheme     financial incentive     caesarean delivery     medical expenditure     China    

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Title Author Date Type Operation

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Journal Article

Studies on preparation of folate-targeted boron liposomes as potential delivery agents for neutron capture

Wang Zhihui,Qin Linxue,Liu Dong

Journal Article

Ca-Alginate-Based Janus Capsules with a Pumping Effect for Intestinal-Targeted Controlled Release

Shuang Wen, XiaoJie Ju, Wenying Liu, Yuqiong Liu, Xingqun Pu, Zhuang Liu, Wei Wang, Rui Xie, Yousef Faraj, Liangyin Chu

Journal Article

Toward Privacy-Preserving Personalized Recommendation Services

Cong Wang, Yifeng Zheng, Jinghua Jiang, Kui Ren

Journal Article

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Journal Article

Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Journal Article

Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

Journal Article

Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Journal Article

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Journal Article

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Journal Article

Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Journal Article